Eribulin-d3 mesylate 是 Eribulin mesylate 的氘代物。Eribulin mesylate 是靶向微管 (microtubule) 的抗癌剂，可用于研究癌症。
货号:ajcx36470
CAS:N/A
分子式:C41H60D3NO14S
分子量：829.02
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Eribulin-d3 mesylate is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et, al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
[2]. Watanabe K, et, al. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4;10(2):161-174.