Erythromycin estolate 是红霉素衍生物，是一种大环内酯类抗生素，用于治疗多种细菌感染。Erythromycin estolate 引起数例肝损伤，主要包括胆汁淤积性肝炎。Erythromycin estolate 的毒性与其对胆汁酸运输的抑制作用有关。
货号:ajcx17058
CAS:3521-62-8
分子式:C52H97NO18S
分子量：1056.39
溶解度:DMSO: 250 mg/mL (236.66 mM)
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Erythromycin estolate, erythromycin derivative[1], is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin estolate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin estolate toxicity is related to its inhibitory effect on bile acid transport[2].

[1]. David E. Kleiner, et al. Learn more about Erythromycin Estolate. Biomaterials and Medical Device - Associated Infections, 2015 [2]. Lu X, et al. Integrated systems toxicology approaches identified the possible involvement of ABC transporters pathway in erythromycin estolate-induced liver injury in rat. Food Chem Toxicol. 2014 Mar;65:343-55.