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5'-pGpG(sodium salt)
本半岛bd体育手机客户端 不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5'-pGpG(sodium salt)图片
包装: 500ug
规格: 98%
市场价: 2230元
分子量: 774.4

半岛bd体育手机客户端 介绍
A linearized form of cyclic di-GMP
货号:ajcx23920
CAS:N/A
分子式:C20H23N10O15P2?3Na
分子量:774.4
溶解度:Water: soluble
纯度:98%
存储:Store at -20°C
库存: 现货

Background:

5'-pGpG is a linearized form of cyclic di-GMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3It is a metabolite of cyclic di-GMP formedviahydrolysis by various phosphodiesterases (PDEs) that binds to the cyclic di-GMP-I riboswitch with reduced affinity compared to cyclic di-GMP.4,55'-pGpG is intended for use as a negative control for cyclic di-GMP signaling.


1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar, K., Zhang, Z., Teles, R.M., et al.DDX41 recognizes bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune responseNat. Immunol.13(12)1155-1161(2012) 3.R?mling, U., Galperin, M.Y., and Gomelsky, M.Cyclic di-GMP: The first 25 years of a universal bacterial second messengerMicrobiol. Mol. Biol. Rev.77(1)1-52(2013) 4.R?mling, U., Galperin, M.Y., and Gomelsky, M.Cyclic di-GMP: The first 25 years of a universal bacterial second messengerMicrobiol. Mol. Biol. Rev.77(1)1-52(2013) 5.Smith, K.D., Lipchock, S.V., and Strobel, S.A.Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamerBiochemistry51(1)425-432(2012)

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