ProsaikogeninG是从柴胡的根中分离出的，对AngII诱导的大鼠系膜细胞增殖具有明显的抑制作用。ProsaikogeninG对肾脏有保护作用。ProsaikogeninG是Saikosaponind在胃肠道中的衍生物。
货号:ajcx31344
CAS:99365-23-8
分子式:C36H58O8
分子量：618.84
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Prosaikogenin G, isolated from the roots of Buleurum bicaule Helm (Apiaceae), exhibits significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Prosaikogenin G has protective action on the kidney[1]. Prosaikogenin G is a derivative of Saikosaponin d in the gastrointestinal tract[2].

Prosaikogenin G (25, 50 μM) has protective action on the kidney for their down-regulated activity to the rat mesangial cell line (MC) proliferation induced by Ang II (1 μM), and does not exhibit injury to the normal MC[1].

[1]. Nan Xu, et al. A new saikogenin from the roots of Bupleurum bicaule. Chin J Nat Med. 2014 Apr;12(4):305-8. [2]. Pei Yu, et al. In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes. Xenobiotica. 2017 Jan;47(1):11-19.