PAO-Nap是NAP(naphthalimide)荧光基团修饰的PAO。PAO通过选择性靶向硫氧蛋白还原酶诱导HL-60细胞氧化应激介导的凋亡。
货号:ajcx31992
CAS:1613402-20-2
分子式:C24H24AsN3O5
分子量：509.39
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].

PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h)[1].

[1]. Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.