SJF620 hydrochloride 是一种 PROTAC BTK 降解剂，DC50 为 7.9 nM。SJF620 含有 Lenalidomide 类似物，可募集 CRBN。
货号:ajcx34072
CAS:N/A
分子式:C41H45ClN8O7
分子量：797.3
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

SJF620 hydrochloride is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].

SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA[1].

SJF620 hydrochloride has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.