A neuropeptide with diverse biological activities
货号:ajcx21476
CAS:N/A
分子式:C12H16N6O4.XH2O
分子量：308.3
溶解度:DMF: 25 mg/ml,DMSO: 14 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：
现货
Background:
5'-N-Ethylcarboxamidoadenosine (NECA) is an adenosine analog that acts as an agonist of adenosine receptors (Kis = 1,880, 6,660, and 3.5 nM for human adenosine subtypes A1, A2A, and A3, respectively).1NECA is reported to act as a potent vasodilator and can inhibit platelet aggregation by increasing cAMP (EC50= 3.1 ?M).2,3
1.Volpini, R., Dal ben, D., Lambertucci, C., et al.N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptorJ. Med. Chem.50(6)1222-1230(2007) 2.de Zwart, M., Link, R., von Frijtag Drabbe K?nzel, J.K., et al.A functional screening of adenosine analogues at the adenosine A2B receptor: a search for potent agonistsNucleosides Nucleotides17(6)969-985(1998) 3.Cusack, N.J., and Hourani, S.M.O.5'-N-ethylcarboxamidoadenosine: A potent inhibitor of human platelet aggregationBr. J. Pharmacol.72(3)443-447(1981)
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