An internal standard for the quantification of ranitidine
货号:ajcx23394
CAS:1185238-09-8
分子式:C13H16D6N4O3S.HCl
分子量：356.9
溶解度:DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Ranitidine-d₆is intended for use as an internal standard for the quantification of ranitidine by GC- or LC-MS. Ranitidine is a histamine H₂receptor antagonist.¹It reverses histamine-induced relaxation of isolated rat uterine horn (pA₂= 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA₂= 7.2). Ranitidine (0.03-3 mg/kg, i.v.) inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats. Formulations containing ranitidine have been used in the treatment and prevention of heartburn and gastroesophageal reflux disease (GERD).

1.Daly, M.J., Humphray, J.M., and Stables, R.Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidineBritish Journal of Pharmacology72(1)49-54(1981)