| 规格: | 98% |
| 分子量: | 414.5 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
Background:
Risperidone-d5is intended for use as an internal standard for the quantification of risperidone by GC- or LC-MS. Risperidone is an atypical antipsychotic that binds to dopamine D2receptors (Ki= 3 nM) and the serotonin (5-HT) receptor subtype 5-HT2A(Ki= 0.12 nM).1,2It also binds to dopamine D4, α1- and α2-adrenergic, 5-HT1C, 5-HT1D, and histamine H1receptors (Kis = 7, 0.81, 7.3, 47, 52, and 2.1 nM, respectively). Risperidone (0.1 mg/kg per day, i.p.) attenuates deficits in prepulse inhibition of the acoustic startle response, but not deficits in social interaction, in a rat neonatal ventral hippocampal lesion model of schizophrenia.3Formulations containing risperidone have been used in the treatment of schizophrenia and bipolar disorder.
1.Leysen, J.E., Janssen, P.M., Gommeren, W., et al.In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidoneMol. Pharmacol.41(3)494-508(1992) 2.Bymaster, F.P., Calligaro, D.O., Falcone, J.F., et al.Radioreceptor binding profile of the atypical antipsychotic olanzapineNeuropsychopharmacology14(2)87-96(1996) 3.Rueter, L.E., Ballard, M.E., Gallagher, K.B., et al.Chronic low dose risperidone and clozapine alleviate positive but not negative symptoms in the rat neonatal ventral hippocampal lesion model of schizophreniaPsychopharmacology (Berl).176(3-4)312-319(2004)
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