A derivative of paclitaxel and an inhibitor of microtubule depolymerization
货号:ajcx26400
CAS:125354-16-7
分子式:C45H55NO15
分子量:849.9
溶解度:DMF: 2 mg/ml,DMSO: 3 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): insol
纯度:98%
存储:Store at -20°C
库存:
现货
Background:
10-acetyl Docetaxel is a derivative of paclitaxel and an inhibitor of microtubule depolymerization.1It inhibits calcium-induced depolymerization of calf brain microtubule protein (MTP) in a cell-free assay when used at 20 ?M. 10-acetyl Docetaxel is cytotoxic to J774.2 cells (EC50= 0.05 ?M).
1.Swindell, C.S., Heerding, J.M., Krauss, N.E., et al.Characterization of the taxol structure-activity profile for the locus of the A-ring side chainBioorg. Med. Chem. Lett.4(12)1531-1536(1994)