IV-361 是一种口服有效，选择性的 CDK7 抑制剂 (Ki≤50 nM)。IV-361 具有抗肿瘤作用 (US20190256531A1)。
货号:ajcx35724
CAS:2055741-39-2
分子式:C23H32FN5O2Si
分子量：457.62
溶解度:DMSO : 90 mg/mL (196.67 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1)[1].

IV-361 has less inhibition on CDK2 (Ki≥1000 nM) or PLK1 (Ki≥5000 nM)[1]. IV-361 exhibits excellent IL-2 and IL-17 production inhibitory activity (all IC50≤100 nM) in periphery blood mononuclear cell (PBMC)[1]. IV-361 exhibits excellent HCT-116 cell growth inhibitory activity (GI50≤100 nM)[1].

IV-361 (25 mg/kg/day; orally) exhibits 46% or more rate of suppression of tumor volume in female BALB nude mice with HCT-116[1].

[1]. Noriaki Iwase, et al. Substituted dihydropyrrolopyrazole derivative. US20190256531A1.