[Sar9,Met(O2)11]-Substance P TFA 是一种选择性的速激肽 NK1 受体激动剂。
货号:ajcx14184
CAS:N/A
分子式:C66H101N18F3O17S
分子量：1507.68
溶解度:H2O: 100 mg/mL (66.33 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK1 receptor selective agonist.

[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming[1].

[1]. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28.