A neuropeptide with diverse biological activities
货号:ajcx21190
CAS:N/A
分子式:C24H47D3NO7P
分子量：498.7
溶解度:Chloroform:Methanol (1:1): soluble,DMF: soluble,DMSO: soluble,Ethanol: 2 mg/ml,PBS (pH 7.2): soluble
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

1-Palmitoyl-d₃-2-hydroxy-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PC by GC- or LC-MS. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A₂(PLA₂) hydrolysis of phosphatidylcholine.¹It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 ?M.²1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 ?M.³It increases TGF-β1 production and enhances Foxp3 protein levels in T_regcells in isolated human peripheral blood when used at a concentration of 10 ?M.⁴1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.⁵

1.Balsinde, J., Winstead, M.V., and Dennis, E.Phospholipase A2 regulation of arachidonic acid mobilizationFEBS Lett.531(1)2-6(2002) 2.Choi, S., Park, S., Liang, G.H., et al.Superoxide generated by lysophosphatidylcholine induces endothelial nitric oxide synthase downregulation in human endothelial cellsCell Physiol. Biochem.25(2-3)233-240(2010) 3.Qin, X., Qiu, C., and Zhao, L.Lysophosphatidylcholine perpetuates macrophage polarization toward classically activated phenotype in inflammationCell. Immunol.289(1-2)185-190(2014) 4.Hasegawa, H., Lei, J., Matsumoto, T., et al.Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-β productionBiochem. Biophys. Res. Commun.415(3)526-531(2011) 5.Yan, J.-J., Jung, J.-S., Lee, J.-E., et al.Therapeutic effects of lysophosphatidylcholine in experimental sepsisNat. Med.10(2)161-167(2004)