生物活性

SH-4-54是一种有效的STAT抑制剂，对STAT3和STAT5的KD为300 nM和464 nM。

靶点信息

STAT3	STAT5
300 nM(Kd)	464 nM(Kd)

化学数据

目录号	A14249
作用机制	Inhibitor (抑制剂)
M. Wt	610.59
Formula	C29H27F5N2O5S
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1456632-40-8
Synonyms	SH454
SMILES	CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F

溶解度

In vitro	DMSO	94 mg/mL (153.94 mM)
	Water	Insoluble
	Ethanol	Warmed: 47 mg/mL (76.97 mM)
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.38 mL	81.89 mL	163.78 mL
0.5 mM	3.28 mL	16.38 mL	32.76 mL
1 mM	1.64 mL	8.19 mL	16.38 mL
5 mM	0.33 mL	1.64 mL	3.28 mL

*The above data is based on the productmolecular weight 610.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.