| 规格: | 98% |
| 分子量: | 356.1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
Background:
Diquat-d12is intended for use as an internal standard for the quantification of diquat by GC- or LC-MS. Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administration has been used to induce oxidative stressin vitroand in animal models.2,3,4It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.2Formulations containing diquat have been used in agriculture for crop desiccation and defoliation.
1.Moreland, D.E.Mechanisms of action of herbicidesAnn. Rev. Plant Physiol.31597-638(1980) 2.Cao, S., Wu, H., Wang, C., et al.Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in pigletsJ. Anim. Sci.96(5)1795-1805(2018) 3.Singh, P., Hanson, P.S., and Morris, C.M.Sirtuin-2 protects neural cells from oxidative stress and is elevated in neurodegenerationParkinsons Dis.2017:2643587(2017) 4.Tom??ek, O., Gabrielov?, B., Ka?er, P., et al.Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signallingSci. Rep.6:23546(2016)
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