您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 半岛bd体育手机客户端 库> JWH 073 N-(4-hydroxybutyl)metabolite-d5
立即咨询
咨询类型:
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
JWH 073 N-(4-hydroxybutyl)metabolite-d5
本半岛bd体育手机客户端 不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JWH 073 N-(4-hydroxybutyl)metabolite-d5图片
规格: 98%
分子量: 348.5
包装与价格:
包装 价格(元)
100ug 电议
500ug 电议
1mg 电议

半岛bd体育手机客户端 介绍
A neuropeptide with diverse biological activities
货号:ajcx22730
CAS:N/A
分子式:C23H16D5NO2
分子量:348.5
溶解度:DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml,DMSO: 30 mg/ml,Ethanol: 0.5 mg/ml
纯度:98%
存储:Store at -20°C
库存: 现货

Background:

JWH 073 N-(4-hydroxybutyl) metabolite-d5contains five deuterium atoms at the 2', 4' ,5', 6', and 7' positions. It is intended for use as an internal standard for the quantification of JWH 073 N-(4-hydroxybutyl) metabolite by GC-or LC-MS. JWH 073 is a mildly selective agonist of the central cannabinoid (CB1) receptor derived from the aminoalkylindole WIN 55,212-2. The Kivalues for binding CB1and the peripheral cannabinoid (CB2) receptor are 8.9 and 38 nM, respectively for a CB1:CB2ratio of 0.23.1JWH 073 is one of several synthetic CBs which have been included in smoking mixtures. JWH 073 N-(4-hydroxybutyl) metabolite is expected to be a major urinary metabolite of JWH 073, characterized by monohydroxylation of the N-alkyl chain, based on the metabolism of the closely-related JWH 015 and JWH 018.2,3In urine samples, this metabolite of JWH 018 is almost completely glucuronidated.3


1.Aung, M.M., Griffin, G., Huffman, J.W., et al.Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor bindingDrug Alcohol Depend.60(2)133-140(2000) 2.Zhang, Q., Ma, P., Cole, R.B., et al.Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MSAnalytical and Bioanalytical Chemistry3861345-1355(2006) 3.Sobolevsky, T., Prasolov, I., and Rodchenkov, G.Detection of JWH-018 metabolites in smoking mixture post-administration urineForensic Sci. Int.200(1-3)141-147(2010)

Baidu
map