A fungal metabolite with diverse biological activities
货号:ajcx23298
CAS:1379585-81-5
分子式:C30H33NO10
分子量：567.6
溶解度:Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Previridicatumtoxin is a fungal metabolite that has been found inP. aethiopicumand has diverse biological activities.^1,2It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin . Previridicatumtoxin is active against methicillin-resistantS. aureus(MRSA) and vancomycin-resistantE. faecalis(IC₅₀s = 4.4 and 4.8 μM, respectively), as well asC. albicansandS. cerevisiae(MIC = 32 μg/ml for both).^2,1It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC₅₀s = 5.3, 4.1, and 6 μM, respectively).²

1.Chooi, Y.H., Wang, P., Fang, J., et al.Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferasesJ. Am. Chem. Soc.134(22)9428-9437(2012) 2.Shang, Z., Salim, A.A., Khalil, Z., et al.Viridicatumtoxins: Expanding on a rare tetracycline antibiotic scaffoldJ. Org. Chem.80(24)12501-12508(2015)