An inhibitor of ferroptosis
货号:ajcx23400
CAS:2584411-86-7
分子式:C18H24OS2
分子量：320.5
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): insouble,PBS (pH 7.2): insouble
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .¹It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a concentration of 25 ?M. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC₅₀= 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT22 cells when used at a concentration of 3 ?M. RC363 inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells (IC₅₀= 173.6 nM).

1.Bueno, D.C., Canto, R.F.S., de Souza, V., et al.New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cellsMol. Neurobiol.57(8)3273-3290(2020)