PF-07104091 是一种高效选择性的 CDK2/cyclin E1 和 GSK3β 抑制剂，其 Ki 分别为 1.16 和 537.81 nM。PF-07104091 对细胞周期素扩增的癌症具有抗肿瘤活性，来自专利 WO2020157652A2。
货号:ajcx34164
CAS:2460249-19-6
分子式:C19H28N6O4
分子量：404.46
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

PF-07104091 is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 has anti-tumor activity for cyclin E1-amplified cancers. (patent WO2020157652A2).

PF-07104091 (Example 13) inhibits CDK1/cyclin A2, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9, with Kis of 110, 238, 465 and 117 nM, respectively[1].

[1]. Douglas Carl BEHENNA, et al. Cdk2 inhibitors. WO2020157652A2.