Thalidomide-O-PEG4-NHS ester 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
货号:ajcx35860
CAS:2411681-88-2
分子式:C28H33N3O13
分子量：619.57
溶解度:DMSO : 83.33 mg/mL (134.50 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562