A nicotinic acetylcholine receptor (nAChR) agonist
货号:ajcx11250
CAS:22083-74-5
分子式:C10H14N2
分子量：162.23
溶解度:>6.8mg/mL in DMSO
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

(±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs; Kis = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively) and possesses addictive and teratogenic properties.1 (?)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (?)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.2
参考文献
1. Zaveri, N., Jiang, F., Olsen, C., et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J. Med. Chem. 53(22), 8187-8191 (2010).
2. Clayton, P., Lu, A., and Bishop, L. The pyrolysis of (?)-(S)-nicotine: Racemization and decomposition. Chirality 22(4), 442-446 (2010).