An internal standard for the quantification of valacyclovir
货号:ajcx22858
CAS:1279033-32-7
分子式:C13H12D8N6O4.HCl
分子量：368.8
溶解度:DMF: 10 mg/ml,DMSO: 3 mg/ml,Ethanol: Insolule,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：
现货
Background:
L-Valacyclovir-d8is intended for use as an internal standard for the quantification of L-valacyclovir by GC- or LC-MS. L-Valacyclovir is an L-valyl prodrug form of the antiviral guanosine analog acyclovir . L-Valacyclovir inhibits herpes simplex virus type 1 (HSV-1) replication (IC50= 0.84 ?M in Vero cells).1It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovirin vitro, however, it is rapidly converted to acyclovirin vivo.2Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.
1.Beauchamp, L.M., Orr, G.F., de Miranda, P., et al.Amino acid ester prodrugs of acyclovirAntivir. Chem. Chemother.3(3)157-164(1992) 2.Beutner, K.R.Valacyclovir: A review of its antiviral activity, pharmacokinetic properties, and clinical efficacyAntiviral Res.28(4)281-290(1995)
m.cnreagent.com
