BRACO 19 trihydrochloride 是一种有效的端粒酶/端粒抑制剂，可防止端粒酶的加帽和催化作用。
货号:ajcx26998
CAS:1177798-88-7
分子式:C35H43N7O2.3HCl
分子量：703.14
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.

Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID:11961134 |Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID:15735037