PSB CB5 是 GRP18 的有效选择性拮抗剂。
货号:ajcx27558
CAS:1627710-30-8
分子式:C20H17ClN2O2S
分子量：384.88
溶解度:7.7mg/ml in DMSO
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Selective GPR18 antagonist (IC50 = 0.279 μM). Exhibits >36-fold selectivity versus CB1 and GPR55 and 14-fold selectivity versus CB2 receptors. Inhibits N-Arachidonylglycine induced acrosomal exocytosis in human spermatozoa.

Rempel et al (2014) Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med.Chem.Comm. 5 632 |Flegel et al (2016) Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci.Rep. 6 32255 PMID:27572937