Hydroxyl functionalized VHL ligand
货号:ajcx27888
CAS:2244684-42-0
分子式:C24H32N4O5S
分子量：488.6
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC? research and development; incorporates an E3 ligase ligand with terminal hydroxyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC? is a registered trademark of Arvinas Operations, Inc., and is used under license.

Maniaci et al (2017) Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Comm. 8 830 PMID:29018234