MefenamicacidD4是Mefenamicacid的氘代物。Mefenamicacid是一种非甾体抗炎剂，为竞争性的hCOX-1和hCOX-2抑制剂，IC50值分别为40nM和3μM。
货号:ajcx31014
CAS:1216745-79-7
分子式:C15H11D4NO2
分子量：245.31
溶解度:DMSO: Slightly soluble,Methanol: Slightly soluble
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].

[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84. [2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.