Tizanidine-d4 是 Tizanidine 的氘代物。Tizanidine 是 α2-肾上腺素受体激动剂，能抑制神经递质从CNS去甲肾上腺素激活的神经元中释放。
货号:ajcx35430
CAS:1188331-19-2
分子式:C9H4D4ClN5S
分子量：257.74
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Tizanidine-d4 is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39.