Chrodrimanin B 是一种真菌的代谢物，是一种有效的、非开放通道阻断 B 的拮抗剂。
货号:ajcx19350
CAS:132196-54-4
分子式:C27H32O8
分子量：484.5
溶解度:DMSO: Soluble,Ethanol: 1 mg/ml,Methanol: Soluble
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Chrodrimanin B is a meroterpenoid fungal metabolite that has been found in Talaromyces species.1 It has insecticidal activity against third instar silkworm larvae (LD50 = 10 μg/g of diet). Chrodrimanin B selectively inhibits the silkworm GABA receptor RDL (IC50 = 1.13 nM) over human α1β2γ2 subunit-containing GABA receptors (IC50 = 1.48 μM).2 The structure of thailandolide B, originally described as a C-9 epimer of chrodrimanin B, was revised in 2012 and is identical to that of chrodrimanin B.1

参考文献
1. Hayashi, H., Oka, Y., Kai, K., et al. A new meroterpenoid, chrodrimanin C, from YO-2 of Talaromyces sp. Biosci. Biotech. Biochem. 76(4), 745-748 (2012).
2. Xu, Y., Furutani, S., Ihara, M., et al. Meroterpenoid chrodrimanins are selective and potent blockers of insect GABA-gated chloride channels. PLoS One 10(4), e0122629 (2015).