A neuropeptide with diverse biological activities
货号:ajcx22908
CAS:N/A
分子式:C13H13D3N3O4S.Na
分子量：336.4
溶解度:DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Metamizole-d₃is intended for use as an internal standard for the quantification of metamizole by GC- or LC-MS. Metamizole is a nonopioid prodrug that is rapidly hydrolyzed to the analgesic and antipyretic metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA).¹It inhibits COX-1 and COX-2 activity (IC₅₀= ~150 ?g/ml for both in cell-free assays), as well as reduces increases in intracellular calcium levels induced by the TRPA1 agonist AITC in isolated rat and mouse dorsal root ganglia and IMR-90 human fibroblasts (IC₅₀s = 30-91 ?M in patch-clamp assays).^2,3Metamizole (6, 12, and 25 ?g/ml) inhibits ADP- and epinephrine-induced platelet aggregation in human platelet-rich plasma (hPRP).⁴It prevents fever induced by LPS, TNF-α, and IL-6, but not arachidonic acid or prostaglandin E₂, in rats when administered at a dose of 120 mg/kg.⁵Metamizole (250 and 500 mg/kg) increases the paw withdrawal threshold in the paw pressure test, indicating analgesic activity, in rat models of carrageenan-induced acute pain and postoperative incision pain.⁶

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