A nucleotide diphosphate
货号:ajcx28424
CAS:402491-35-4
分子式:C10H12N5O9P2 ? 3Na
分子量：477.2
溶解度:PBS (pH 7.2): 10mg/mL
纯度：98%
存储：Store at -20°C
库存：
现货
Background:
2’-Deoxyadenosine-5’-diphosphate (dADP) is a purine nucleotide diphosphate.1It inhibits the polymerization of ADP and CDP byE. coliorP. fluorescenspolynucleotide phosphorylase when used at a concentration of 0.23 mM.2dADP levels are increased in erythrocytes isolated from patients with adenosine deaminase (ADA) deficiency, an inborn error of metabolism characterized by severe combined immunodeficiency (SCID).3
1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide biosynthesisBiochemistry(2002) 2.Lucas-Lenard, J.M., and Cohen, S.S.The inhibition of polynucleotide phosphorylase by certain substrate analoguesBiochim. Biophys. Acta123(3)471-477(1966) 3.Coleman, M.S., Donofrio, J., Hutton, J.J., et al.Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiencyJ. Biol. Chem.253(5)1619-1626(1978)
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