AR-C102222 hydrochloride 是一种有效的、竞争性的、有口服活性的、高度选择性的诱导型一氧化氮合酶 (iNOS) 抑制剂，IC50 值为 37 nM。AR-C102222 hydrochloride 具有镇痛和抗炎活性。
货号:ajcx15256
CAS:1781934-50-6
分子式:C19H17ClF2N6O
分子量：418.83
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM[1]. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities[2].

AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity[2].AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model[3]. Animal Model: Male Balb/c mice (20-25 g)[2].

[1]. Tinker AC, et al. 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J Med Chem. 2003 Mar 13;46(6):913-6. [2]. LaBuda CJ, et al. Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain. Eur J Pain. 2006 Aug;10(6):505-12. Epub 2005 Aug 24. [3]. Yoon J, et al. Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1953-7.