A neuropeptide with diverse biological activities
货号:ajcx20030
CAS:N/A
分子式:C39H29D8F6N3O2
分子量:701.8
溶解度:Acetonitrile: soluble
纯度:98%
存储:Store at -20°C
库存:
现货
Background:
Lomitapide-d8 is intended for use as an internal standard for the quantification of lomitapide by GC- or LC-MS. Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTTP; IC50 = 0.5 nM in a triglyceride transfer assay).1 It inhibits apolipoprotein B (ApoB) secretion in HepG2 cells (EC50 = 0.8 nM). Lomitapide inhibits triglyceride secretion in fasted rats (ED50 = 0.19 mg/kg, p.o.) and reduces total plasma cholesterol levels in hamsters (ED50 = 2.4 mg/kg). It also decreases plasma cholesterol and triglyceride levels in the Watanabe-heritable hyperlipidemic (WHHL) rabbit model of homozygous familial hypercholesterolemia when administered at a dose of 10 mg/kg. Formulations containing lomitapide have been used as an adjunct to a low-fat diet and other lipid-lowering treatments in the treatment of homozygous familial hypercholesterolemia.
|1. Wetterau, J.R., Gregg, R.E., Harrity, T.W., et al. An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. Science 282(5389), 751-754 (1998).