Pavinetant(MLE-4901)是一种神经激肽-3受体(NK3R)拮抗剂。
CAS：941690-55-7
分子式：C26H25N3O3S
分子量：459.56
纯度：98%
存储：Store at -20°C

Background:

Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.

Pavinetant (AZD2624) is a potent and selective NK3 receptor antagonist which is developed for the treatment of schizophrenia. Pavinetant exhibits an inhibitory effect on microsomal CYP3A4/5 activities with apparent IC50 values of 7.1 and 19.8 μM for midazolam and testosterone assays, respectively. No time-dependent inactivation of CYP3A4/5 activity by Pavinetant is observed. Pavinetant demonstrates weak to no inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2D6[1].

[1]. Li Y, et al. In vitro assessment of metabolic drug-drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies. Xenobiotica. 2010 Nov;40(11):721-9.