ORM-15341是一种有效的雄激素受体(AR)拮抗剂,作用于AR-HEK293细胞,IC50值为38nM。
CAS：1297537-33-7
分子式：C19H17ClN6O2
分子量：396.83
纯度：98%
存储：Store at -20°C

Background:

ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.IC50 value: 38 nMTarget: androgen receptorin vitro: In competitive AR binding assays, the inhibition constant (Ki) values of ORM-15341 was 8 nM. ORM-15341 functions as a full antagonist for all tested mutant ARs , with IC50 of 25, 51, 700, and 1160 nM for wtAR, AR(F876L), AR(T877A), and AR(W741L).

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