尾1-selective adrenoceptor antagonist
CAS锛?7460-41-0
鍒嗗瓙寮忥細C20H33N3O3
鍒嗗瓙閲忥細363.5
绾害锛?8%
瀛樺偍锛歋tore at -20掳C

Background:

(卤)-Talinolol is a selective 尾1 adrenoceptor antagonist with cardioprotective and antihypertensive activity.

尾 adrenoceptor antagonist is a class of medications that are particularly used to manage cardiac arrhythmias, and to protect the heart from a second heart attack after a first heart attack.

By blocking 尾1-adrenergic receptors, (卤)-talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity [1]. Pharmacokinetic data of the time course of plasma concentrations following intravenous infusion of 30 mg (卤)-Talinolol revealed that the peak serum concentration (Cmax), the area under the serum concentration-time curve (AUC), and terminal elimination halflife (t1/2) were 631卤95 ng/ml, 1433卤153 ng脳h/ml, and 10.6卤3.3 h, respectively. Pharmacokinetic data of the time course of plasma concentrations following oral administration of 50 mg (卤)-Talinolol revealed that the Cmax, the AUC, and the t1/2 were 168卤67 ng/ml, 1321卤382 ng脳h/ml, and 11.9卤2.4 h, respectively [2].

鍙傝€冩枃鐚?
[1] Abmann I. The actions of talinolol, a 尾1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction[J]. Current Medical Research and Opinion, 2008, 13(6): 325-342.
[2] Trausch B, Oertel R, Richter K, et al. Disposition and bioavailability of the 尾1鈥恆drenoceptor antagonist talinolol in man[J]. Biopharmaceutics & Drug Disposition, 1995, 16(5): 403-414.