生物活性

Cerdulatinib (PRT-062070)是多靶点酪氨酸激酶抑制剂，对JAK1/JAK2/JAK3/TYK2和Syk的IC50分别为12 nM/6 nM/8 nM/0.5 nM和32 nM。

Targets

Target	Value
TYK2	IC50: 0.5nM
MST1	IC50: 4nM
ARK5	IC50: 4nM
MLK1	IC50: 5nM
Fms	IC50: 5nM
AMPK	IC50: 6nM
JAK2	IC50: 6nM
JAK3	IC50: 8nM
TBK1	IC50: 10nM
MARK1	IC50: 10nM
JAK1	IC50: 12nM
PAR1B-a	IC50: 13nM
TSSK	IC50: 14nM
MST2	IC50: 15nM
GCK	IC50: 18nM
JNK3	IC50: 18nM
RSK2	IC50: 20nM
RSK4	IC50: 28nM
Syk	IC50: 32nM
Chk1	IC50: 42nM
FLT4	IC50: 51nM
FLT3	IC50: 90nM
RET	IC50: 105nM
ITK	IC50: 194nM

化学数据

目录号	A14210
作用机制	Inhibitor (抑制剂)
M. Wt	482
Formula	C20H28ClN7O3S
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1369761-01-2
Synonyms	PRT062070, PRT2070, PRT-2070
SMILES	CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N.Cl

溶解度

In vitro (25°C)	DMSO	Warmed: 42 mg/mL (87.14 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+corn oil	2 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.75 mL	103.73 mL	207.47 mL
0.5 mM	4.15 mL	20.75 mL	41.49 mL
1 mM	2.07 mL	10.37 mL	20.75 mL
5 mM	0.41 mL	2.07 mL	4.15 mL

*The above data is based on the productmolecular weight 482. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.