Nafarelin是促性腺激素释放激素(GnRH)的激动剂,它能促进促黄体激素(LH)和促卵泡激素(FSH)的分泌。
CAS:76932-56-4
分子式:C66H83N17O13
分子量:1322.47
纯度:98%
存储:Store at -20°C
Background:
Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)[1]. Nafarelin is used effectively in in vitro fertilisation programmes. Nafarelin is readily and rapidly absorbed following intranasal delivery, and is protected to some extent from enzymatic degradation GnRH[2].
[1]. Letassy NA et al. Nafarelin acetate: a gonadotropin-releasing hormone agonist for the treatment of endometriosis. DICP. 1990 Dec, 24(12):1204-9. [2]. Chrisp P et al. Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions.Drugs. 1990 Apr;39(4):523-51.