生物活性

Hydroxychloroquine Sulfate是一种抗疟疾药，用于治疗系统性红斑狼疮，类风湿性关节炎和其他自身免疫性，炎性和皮肤病性疾病。还可以作为自噬和通行费样受体（TLR）7/9的抑制剂。

靶点信息

TLR9	Autophagy

化学数据

目录号	A14208
M. Wt	433.95
Formula	C18H28ClN3O5S
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	747-36-4
SMILES	CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O

溶解度

In vitro	DMSO	Insoluble
	Water	58 mg/mL (133.65 mM)
	Ethanol	Insoluble
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.04 mL	115.22 mL	230.44 mL
0.5 mM	4.61 mL	23.04 mL	46.09 mL
1 mM	2.3 mL	11.52 mL	23.04 mL
5 mM	0.46 mL	2.3 mL	4.61 mL

*The above data is based on the productmolecular weight 433.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.