生物活性

LCZ696 (Valsartan)是一种生物利用型双效血管紧张素受体-中性溶血素抑制剂（ARNi），用于治疗高血压和心力衰竭。

靶点信息

RAAS

化学数据

目录号	A14206
作用机制	Inhibitor (抑制剂)
M. Wt	915.98
Formula	C24H29N5O3.C24H29NO5.5/2H2O.3Na
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	936623-90-4
Synonyms	LCZ 696, LCZ-696
SMILES	CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O.CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O.O.O.O.[Na+].[Na+].[Na+]

溶解度

In vitro	DMSO	Warmed: 26 mg/mL (28.38 mM)
	Water	Warmed: 88 mg/mL (96.07 mM)
	Ethanol	Warmed: 8 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.92 mL	54.59 mL	109.17 mL
0.5 mM	2.18 mL	10.92 mL	21.83 mL
1 mM	1.09 mL	5.46 mL	10.92 mL
5 mM	0.22 mL	1.09 mL	2.18 mL

*The above data is based on the productmolecular weight 915.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.