生物活性

HPOB是组蛋白去乙酰化酶6(HDAC6；IC50 = 56 nM)。

Targets

Target	Value
HDAC6	IC50: 56nM
HDAC3	IC50: 1.7μM
HDAC8	IC50: 2.8μM
HDAC1	IC50: 2.9μM
HDAC10	IC50: 3.0μM
HDAC2	IC50: 4.4μM
HDAC4	IC50: >10μM
HDAC5	IC50: >10μM
HDAC7	IC50: >10μM
HDAC9	IC50: >10μM
HDAC11	IC50: >10μM

化学数据

目录号	A14197
作用机制	Inhibitor (抑制剂)
M. Wt	314.3
Formula	C17H18N2O4
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1429651-50-2
Synonyms	0
SMILES	C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO

溶解度

In vitro	DMSO	60 mg/mL (190.87 mM)
	Water	Insoluble
	Ethanol	Warmed: 37 mg/mL (117.7 mM)
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.82 mL	159.08 mL	318.17 mL
0.5 mM	6.36 mL	31.82 mL	63.63 mL
1 mM	3.18 mL	15.91 mL	31.82 mL
5 mM	0.64 mL	3.18 mL	6.36 mL

*The above data is based on the productmolecular weight 314.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.