生物活性

LY2801653 (Merestinib)是一种有效的，口服生物利用的小分子c-MET激酶抑制剂（Ki = 2 nM）。

靶点信息

Met
2 nM(Ki)

化学数据

目录号	A12557
作用机制	Inhibitor (抑制剂)
M. Wt	552.53
Formula	C30H22F2N6O3
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1206799-15-6
Synonyms	LY-2801653, Merestinib
SMILES	O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3

溶解度

In vitro	DMSO	88 mg/mL (159.26 mM)
	Water	Insoluble
	Ethanol	88 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.1 mL	90.49 mL	180.99 mL
0.5 mM	3.62 mL	18.1 mL	36.2 mL
1 mM	1.81 mL	9.05 mL	18.1 mL
5 mM	0.36 mL	1.81 mL	3.62 mL

*The above data is based on the productmolecular weight 552.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.