生物活性

Necrostatin-1是一种与ATP竞争的，与受体相互作用的蛋白激酶1（RIPK1）的变构抑制剂（EC50 = 182 nM）。

靶点信息

RIP1 (293T cells)
490 nM(EC50)

化学数据

目录号	A11973
作用机制	Inhibitor (抑制剂)
M. Wt	259.33
Formula	C13H13N3OS
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	4311-88-0
SMILES	CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32

溶解度

In vitro (25°C)	DMSO	Warmed: 43 mg/mL (165.81 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+45% PEG 300+ddH2O	9 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	38.56 mL	192.8 mL	385.61 mL
0.5 mM	7.71 mL	38.56 mL	77.12 mL
1 mM	3.86 mL	19.28 mL	38.56 mL
5 mM	0.77 mL	3.86 mL	7.71 mL

*The above data is based on the productmolecular weight 259.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.