生物活性

IM-12是一种细胞渗透性吲哚标记，作为糖原合成酶激酶3β（GSK-3β）抑制剂，激活典型Wnt信号的下游成分。

靶点信息

GSK-3β
53 nM

化学数据

目录号	A14196
作用机制	Inhibitor (抑制剂)
M. Wt	377.41
Formula	C22H20FN3O2
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1129669-05-1
Synonyms	IM12, IM 12
SMILES	CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F

溶解度

In vitro	DMSO	72 mg/mL (190.77 mM)
	Water	Insoluble
	Ethanol	Warmed: 10 mg/mL (26.49 mM)
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.5 mL	132.48 mL	264.96 mL
0.5 mM	5.3 mL	26.5 mL	52.99 mL
1 mM	2.65 mL	13.25 mL	26.5 mL
5 mM	0.53 mL	2.65 mL	5.3 mL

*The above data is based on the productmolecular weight 377.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.