生物活性

LY2874455是一种新型有效的FGFR / VEGFR抑制剂。

靶点信息

FGFR2	FGFR1	FGFR4	FGFR3	VEGFR2
2.6 nM	2.8 nM	6 nM	6.4 nM	7 nM

化学数据

目录号	A11244
作用机制	Inhibitor (抑制剂)
M. Wt	444.31
Formula	C21H19Cl2N5O2
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1254473-64-7
Synonyms	LY-2874455, LY2874455
SMILES	C[C@H](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3/C=C/C4=CN(N=C4)CCO

溶解度

In vitro (25°C)	DMSO	86 mg/mL (193.55 mM)
	Water	Insoluble
	Ethanol	Warmed: 56 mg/mL (126.03 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.51 mL	112.53 mL	225.07 mL
0.5 mM	4.5 mL	22.51 mL	45.01 mL
1 mM	2.25 mL	11.25 mL	22.51 mL
5 mM	0.45 mL	2.25 mL	4.5 mL

*The above data is based on the productmolecular weight 444.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.