生物活性

PTC124也称为Ataluren，是CFTR-G542X无意义等位基因抑制剂。

靶点信息

CFTR (HEK293 cells)

化学数据

目录号	A10758
作用机制	Inhibitor (抑制剂)
M. Wt	284.2
Formula	C15H9FN2O3
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	775304-57-9
Synonyms	PTC-124, PTC 124
SMILES	C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F

溶解度

In vitro (25°C)	DMSO	55 mg/mL (193.49 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.19 mL	175.93 mL	351.86 mL
0.5 mM	7.04 mL	35.19 mL	70.37 mL
1 mM	3.52 mL	17.59 mL	35.19 mL
5 mM	0.7 mL	3.52 mL	7.04 mL

*The above data is based on the productmolecular weight 284.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.