生物活性

PHA-680632是Aurora A，Aurora B和Aurora C的有效抑制剂，IC50分别为27 nM，135 nM和120 nM。对于FGFR1，FLT3，LCK，PLK1，STLK2和VEGFR2/3，它的IC50高10到200倍。

Targets

Target	Value
AuroraA	IC50: 27nM
AuroraC	IC50: 120nM
AuroraB	IC50: 135nM
FGFR1	IC50: 390nM
PLK1	IC50: 780nM
FLT3	IC50: 820nM
VEGFR3	IC50: 1000nM
VEGFR2	IC50: 1920nM
LCK	IC50: 1950nM
STLK2	IC50: 5500nM

化学数据

目录号	A10714
作用机制	Inhibitor (抑制剂)
M. Wt	501.6
Formula	C28H35N7O2
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	398493-79-3
Synonyms	PHA680632
SMILES	CCC1=C(C(=CC=C1)CC)NC(=O)N2CC3=C(C2)NN=C3NC(=O)C4=CC=C(C=C4)N5CCN(CC5)C

溶解度

In vitro (25°C)	DMSO	91 mg/mL (181.41 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+50% PEG 300+5% Tween 80+ddH2O	14 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.94 mL	99.68 mL	199.36 mL
0.5 mM	3.99 mL	19.94 mL	39.87 mL
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.4 mL	1.99 mL	3.99 mL

*The above data is based on the productmolecular weight 501.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.