生物活性

PHA665752是c-Met/HGF/SF信号传导的小分子抑制剂。

Targets

Target	Value
c-Met	IC50: 9nM
RON	IC50: 68nM
Flk1	IC50: 200nM
c-Abl	IC50: 1.4μM
FGFR1	IC50: 3μM
EGFR	IC50: 3.8μM
c-Src	IC50: 6μM
IGF-1R	IC50: >10μM
PDGFR	IC50: >10μM
AuroraA2	IC50: >10μM
PKA	IC50: >10μM
PKBα	IC50: >10μM
CDK2	IC50: >10μM
p38α	IC50: >10μM
MK2	IC50: >10μM
MK3	IC50: >10μM

化学数据

目录号	A10713
作用机制	Inhibitor (抑制剂)
M. Wt	641.6
Formula	C32H34Cl2N4O4S
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	477575-56-7
Synonyms	PHA665752
SMILES	CC1=C(NC(=C1C(=O)N2CCC[C@@H]2CN3CCCC3)C)/C=C\4/C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O

溶解度

In vitro (25°C)	DMSO	124 mg/mL (193.26 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+castor oil	4 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.59 mL	77.93 mL	155.86 mL
0.5 mM	3.12 mL	15.59 mL	31.17 mL
1 mM	1.56 mL	7.79 mL	15.59 mL
5 mM	0.31 mL	1.56 mL	3.12 mL

*The above data is based on the productmolecular weight 641.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.