生物活性

OSU-03012 (AR-12)是一种有效的重组PDK-1(phosphoinositide-dependent kinase 1)抑制剂。

靶点信息

PDK-1 (Cell-free assay)
5 μM

化学数据

目录号	A10681
作用机制	Inhibitor (抑制剂)
M. Wt	460.2
Formula	C26H19F3N4O
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	742112-33-0
SMILES	C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F

溶解度

In vitro (25°C)	DMSO	10 mg/mL (21.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.73 mL	108.65 mL	217.3 mL
0.5 mM	4.35 mL	21.73 mL	43.46 mL
1 mM	2.17 mL	10.86 mL	21.73 mL
5 mM	0.43 mL	2.17 mL	4.35 mL

*The above data is based on the productmolecular weight 460.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.