生物活性

Nilotinib (AMN-107)是一种Bcr-Abl抑制剂，IC50小于30 nM。

靶点信息

Bcr-Abl (Murine myeloid progenitor cells)
<30 nM

化学数据

目录号	A10644
作用机制	Inhibitor (抑制剂)
M. Wt	529.5
Formula	C28H22F3N7O
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	641571-10-0
Synonyms	AMN107
SMILES	CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5

溶解度

In vitro (25°C)	DMSO	26 mg/mL (49.09 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	2 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.89 mL	94.43 mL	188.86 mL
0.5 mM	3.78 mL	18.89 mL	37.77 mL
1 mM	1.89 mL	9.44 mL	18.89 mL
5 mM	0.38 mL	1.89 mL	3.78 mL

*The above data is based on the productmolecular weight 529.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.