生物活性

Nelarabine是一种嘌呤核苷类似物，可转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸（araGTP），从而抑制DNA合成和细胞毒性，IC50为0.067-2.15 μM。

靶点信息

DNA synthesis (PER-255 cells)	DNA synthesis (HSB2 cells)	DNA synthesis (ALL-SIL cells)	DNA synthesis (JURKAT cells)
67 nM	0.44 μM	1.24 μM	2.15 μM

化学数据

目录号	A10632
M. Wt	297.3
Formula	C11H15N5O5
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	121032-29-9
Synonyms	506U78
SMILES	COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N

溶解度

In vitro (25°C)	DMSO	55 mg/mL (185.01 mM)
	Water	3 mg/mL (10.09 mM)
	Ethanol	Insoluble
In vivo	saline	2 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.64 mL	168.18 mL	336.36 mL
0.5 mM	6.73 mL	33.64 mL	67.27 mL
1 mM	3.36 mL	16.82 mL	33.64 mL
5 mM	0.67 mL	3.36 mL	6.73 mL

*The above data is based on the productmolecular weight 297.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.